The Mullins laboratory is located in the Rosen Building on the South Lake Union campus of the University of Washington School of Medicine. Our lab uses molecular, computational, and virus biology techniques to provide insights into the relationship between HIV and its human hosts in an effort to fight the AIDS pandemic. We use a variety of methods to document and understand the implications of HIV's extraordinary genetic diversity on the immunopathogenesis of AIDS, with a particular emphasis on acute/early infection and superinfection. We then apply this information to develop more effective vaccines and therapies in collaboration with other investigators. Our research work focuses on the acquisition and computational characterization of HIV nucleotide sequences, the development of web tools for related computational studies, in vitro studies of the growth properties of viral isolates, host genetic polymorphism analysis, and high-throughput analysis of cellular transcription.

Lab News

New research featured in Science

"Cancer Genes Help HIV Persist, Complicating Cure Efforts."Science News & Analysis, 14 March 2014

RV144 Analysis Featured by Nature

"Vaccine trial reveals chinks in HIV's armour."Nature | News, 10 September 2012

Step Trial Analysis Featured in UW Today

"For first time, scientists show an HIV vaccine impacts the genetic makeup of the virus." UW Today, 1 March 2011


Recent Publications

Manocheewa S, Lanxon-Cookson EC, Liu Y, Swain JV, McClure J, Rao U, Maust B, Deng W, Sunshine JE, Kim M, Rolland M, Mullins JI 2015 Pairwise growth competition assay for determining the replication fitness of human immunodeficiency viruses. Journal of visualized experiments : J. Vis. Exp.(99), e52610, doi:10.3791/52610 pubmed

Mackelprang RD, Carrington M, Thomas KK, Hughes JP, Baeten JM, Wald A, Farquhar C, Fife K, Campbell MS, Kapiga S, Gao X, Mullins JI, Lingappa JR 2015 Host genetic and viral determinants of HIV-1 RNA set point among HIV-1 seroconverters from sub-saharan Africa. Journal of virology8942104-11 pubmed

Mothe B, Hu X, Llano A, Rosati M, Olvera A, Kulkarni V, Valentin A, Alicea C, Pilkington GR, Sardesai NY, Rocafort M, Crespo M, Carrillo J, Marco A, Mullins JI, Dorrell L, Hanke T, Clotet B, Pavlakis GN, Felber BK, Brander C 2015 A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques. Journal of translational medicine13160 pubmed

Maenza J, Tapia K, Holte S, Stekler JD, Stevens CE, Mullins JI, Collier AC 2015 How often does treatment of primary HIV lead to post-treatment control? Antiviral therapyEpub ahead of print pubmed

Herbeck J, Ghorai S, Chen L, Rinaldo CR, Margolick JB, Detels R, Jacobson L, Wolinsky S, Mullins JI 2015 p21WAF1/CIP1 RNA Expression in Highly HIV-1 Exposed, Uninfected Individuals. PloS one103e0119218 pubmed

Department of Microbiology
School of Medicine
University of Washington
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