Mullins Molecular Retrovirology Lab
The Mullins laboratory is located in the Rosen Building on the South Lake Union campus of the University of Washington School of Medicine. Our lab uses molecular, computational, and virus biology techniques to provide insights into the relationship between HIV and its human hosts in an effort to fight the AIDS pandemic. We use a variety of methods to document and understand the implications of HIV's extraordinary genetic diversity on the immunopathogenesis of AIDS, with a particular emphasis on acute/early infection and superinfection. We then apply this information to develop more effective vaccines and therapies in collaboration with other investigators. Our research work focuses on the acquisition and computational characterization of HIV nucleotide sequences, the development of web tools for related computational studies, in vitro studies of the growth properties of viral isolates, host genetic polymorphism analysis, and high-throughput analysis of cellular transcription.
New research featured in Science
RV144 Analysis Featured by Nature
Step Trial Analysis Featured in UW Today
Lack of viral control and development of combination antiretroviral therapy escape mutations in macaques after bone marrow transplantation.
AIDS (London, England)29131597-606
HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders.
Nature medicineEpub ahead of print pubmed
Comparison of Major and Minor Viral SNPs Identified through Single Template Sequencing and Pyrosequencing in Acute HIV-1 Infection.
Resistance detected by pyrosequencing following zidovudine monotherapy for prevention of HIV-1 mother-to-child-transmission.
AIDS (London, England)29121467-71
Fitness-balanced escape determines resolution of dynamic founder virus escape processes in HIV-1 infection.
Journal of virologyEpub ahead of print pubmed
Department of Microbiology
School of Medicine
University of Washington