Mullins Molecular Retrovirology Lab
The Mullins laboratory is located in the Rosen Building on the South Lake Union campus of the University of Washington School of Medicine. Our lab uses molecular, computational, and virus biology techniques to provide insights into the relationship between HIV and its human hosts in an effort to fight the AIDS pandemic. We use a variety of methods to document and understand the implications of HIV's extraordinary genetic diversity on the immunopathogenesis of AIDS, with a particular emphasis on acute/early infection and superinfection. We then apply this information to develop more effective vaccines and therapies in collaboration with other investigators. Our research work focuses on the acquisition and computational characterization of HIV nucleotide sequences, the development of web tools for related computational studies, in vitro studies of the growth properties of viral isolates, host genetic polymorphism analysis, and high-throughput analysis of cellular transcription.
New research featured in Science
RV144 Analysis Featured by Nature
Step Trial Analysis Featured in UW Today
A Novel T-cell Vaccine Eliciting T-cell Specificities Associated with Control of HIV-1 In Humans Is Highly Immunogenic in Mice and Macaques.
AIDS research and human retroviruses30 Suppl 1A76
Expanded Epitope Recognition by Vaccination with DNA Encoding Novel Immunogens Comprising HIV Conserved Elements.
AIDS research and human retroviruses30 Suppl 1A45-6
Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial.
AIDS research and human retroviruses30 Suppl 1A25-6
CD8 and CD4 Epitope Predictions in RV144: No Strong Evidence of a T-Cell Driven Sieve Effect in HIV-1 Breakthrough Sequences from Trial Participants.
HIV-1 Conserved Elements p24CE DNA Vaccine Induces Humoral Immune Responses with Broad Epitope Recognition in Macaques.
Department of Microbiology
School of Medicine
University of Washington