Mullins Molecular Retrovirology Lab
The Mullins laboratory is located in the Rosen Building on the South Lake Union campus of the University of Washington School of Medicine. Our lab uses molecular, computational, and virus biology techniques to provide insights into the relationship between HIV and its human hosts in an effort to fight the AIDS pandemic. We use a variety of methods to document and understand the implications of HIV's extraordinary genetic diversity on the immunopathogenesis of AIDS, with a particular emphasis on acute/early infection and superinfection. We then apply this information to develop more effective vaccines and therapies in collaboration with other investigators. Our research work focuses on the acquisition and computational characterization of HIV nucleotide sequences, the development of web tools for related computational studies, in vitro studies of the growth properties of viral isolates, host genetic polymorphism analysis, and high-throughput analysis of cellular transcription.
New research featured in Science
RV144 Analysis Featured by Nature
Step Trial Analysis Featured in UW Today
Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial.
PLoS computational biology112e1003973
Performance of commonly used genotypic assays and comparison with phenotypic assays of HIV-1 coreceptor tropism in acutely HIV-1-infected patients.
The Journal of antimicrobial chemotherapyEpub ahead of print pubmed
Spontaneous control of HIV-1 viremia in a subject with protective HLA-B plus HLA-C alleles and HLA-C associated single nucleotide polymorphisms.
Journal of translational medicine12:335
Host Genetic and Viral Determinants of HIV-1 RNA Set Point among HIV-1 Seroconverters from Sub-Saharan Africa.
Journal of virology8942104-11
A Novel T-cell Vaccine Eliciting T-cell Specificities Associated with Control of HIV-1 In Humans Is Highly Immunogenic in Mice and Macaques.
AIDS research and human retroviruses30 Suppl 1A76
Department of Microbiology
School of Medicine
University of Washington